Home
ColinsAI
Graph neural networks

Tissue & Gene Network Simulation

Using our Graph AI model, we simulate both paracrine signaling throughout the tissue microenvironment as well as the Gene Regulatory Network to find out what the drivers of the disease are and how your drug will perform.

Inter & Intra Cellular Signaling

Our model is composed of 2 embedded graphs. At the top level, we model individual cells within a tissue as nodes and inter cellular signaling as edges. Inside every cell node, there is a lower level Gene Expression Network Graph that models inter cellular communication.

Quality

Cell Communication & Gene Expression

We don't just look at isolated cells. Our Graph AI models the entire tissue, from the physical neighborhood to the internal genetic circuit, ensuring you fully map both inter and intra cellular interactions.

Spatial Transcriptomics

We map exactly how cells talk to each other. By modeling paracrine signaling, the AI predicts how your drug penetrates deep tissue and where it might be blocked.

Gene Regulatory Networks

We identify the Transcription Factors that act as hubs for the disease. Hitting these master regulators is like turning off the lights rather than catching every photon.

Resistance Prediction

Our model simulates the backup pathways a cell might use to survive your treatment. We help you stay one step ahead of drug resistance before it happens in patients.

Data Fusion

Whether you have 10x Visium, Xenium, or scRNA-seq data, our GNN merges these different resolutions into a single, high-fidelity biological graph.

Deliverables

Your Evidence Package

We provide the deep biological evidence you need for regulatory filings, funding rounds, and clinical trial strategy.

Spatial Biomarker List

A precise list of coordinates and gene signatures that define which patients will respond to your drug.

Interaction Maps (.PDF/HTML)

Fully interactive tissue maps showing drug penetration, cell-cell communication, and active signaling pathways.

Network Impact Report

A detailed audit of how your treatment re-wires the cellular network, highlighting master regulators and potential off-target risks.

Integration

Secure, On-Premise Deployment

We guarantee absolute privacy for your proprietary targets. Our engine is fully containerized and can be deployed On-Premise (air-gapped) or via Private Cloud, ensuring your data never leaves your firewall.

AWS logo
Databricks logo
Snowflake logo
NVIDIA logo
Azure logo
Benchling logo
Schrodinger logo
Dotmatics logo
Oracle logo